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Endogenous corticotropin releasing factor (CRF) has been documented to play a critical role in many neuroendocrine and non-neuroendocrine functions. The effects of the second member of the CRF family, corticotropin releasing peptide (CRP), on the survival of cerebral microvascular endothelial cells are less explored. Here, we investigated the influence of urocortin (URO)-3 on the apoptosis of human cerebral microvascular endothelial cells. The results showed that the CRF receptor 1 (CRFR1) is expressed in human cerebral microvascular endothelial cells. 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